The ubiquitin connection
نویسندگان
چکیده
منابع مشابه
PHD domains and E3 ubiquitin ligases: viruses make the connection.
PHD domains constitute a widely distributed subfamily of zinc fingers whose biochemical functions have been unclear until now. Recently, several PHD-containing viral proteins have been identified that promote immune evasion by downregulating proteins that govern immune recognition. Studies show that these viral regulators lead to ubiquitination of their targets by functioning as E3 ubiquitin li...
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The ubiquitin (Ub) system is centered on conjugation and deconjugation of Ub and Ub-like (Ubls) proteins by a system of ligases and peptidases, respectively. Ub/Ubls contain the beta-grasp fold, also found in numerous proteins with biochemically distinct roles unrelated to the conventional Ub-system. The beta-GF underwent an early radiation spawning at least seven clades prior to the divergence...
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ژورنال
عنوان ژورنال: Nature
سال: 2002
ISSN: 0028-0836,1476-4687
DOI: 10.1038/416381a